Inter-laboratory variation in B cell subsets reporting and its clinical implications

Common variable immunodeficiency (CVID) affects approximately 1 in 30,000 individuals and is caused by defective B cell differentiation. Clinical presentations laboratory anomalies guide the diagnosis of CVID. Given switched memory levels below 70% related age adjusted reference interval are considered consistent with CVID, we sought to assess performance laboratories subsets program offered RCPAQAP. Method: An analysis inter-laboratory variation reporting all method groups from 2020 2022 was performed. Results: The CV cells as a percentage significantly improved 2021 compared (p<0.006) where mean decreased 65% 24%. 30%. peripheral blood lymphocytes also showed significant ongoing improvement (p<0.005), reduced 64% 33% 2021, 31% 2022. Conclusion: While imprecision has improved, level should still be when assessing monitoring